Distribution and urinary excretion of the desethylmetabolites of chloroquine in the rat
Identifieur interne : 003352 ( Main/Exploration ); précédent : 003351; suivant : 003353Distribution and urinary excretion of the desethylmetabolites of chloroquine in the rat
Auteurs : L. A. Salako [Nigeria] ; Funmilayo O. Ajayi [Nigeria]Source :
- Journal of Pharmacy and Pharmacology [ 0022-3573 ] ; 1987-10.
English descriptors
- Teeft :
Abstract
The tissue distribution of desethylchloroquine and bis‐desethylchloroquine has been studied in rats after single intraperitoneal administration of the drugs at a dose of 10 mg kg−1. Concentrations of the chloroquine metabolites in the liver, heart, lungs, kidney and spleen were 34 to 250 times higher than their plasma concentrations 24 h after the drugs had been injected. Urinary excretion of the drugs was studied in rats after single intravenous administration of 2ṁ5, 5 or 10 mg kg−1 doses. The total estimated urinary excretion of desethylchloroquine and bisdesethylchloroquine was 25 and 64% respectively of the administered dose, with the maximum urinary excretion occurring on the first day. The results show that the desethylmetabolites of chloroquine are concentrated in the tissues in the same manner as the parent compound.
Url:
DOI: 10.1111/j.2042-7158.1987.tb05136.x
Affiliations:
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A." last="Salako">L. A. Salako</name><affiliation wicri:level="4"><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Pharmacology & Therapeutics, University of Ibadan, Ibadan</wicri:regionArea><orgName type="university">Université d'Ibadan</orgName><placeName><settlement type="city">Ibadan</settlement><region type="region">État d'Oyo</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Nigeria</country><wicri:regionArea>Correspondence address: Department of Pharmacology & Therapeutics, University of Ibadan, Ibadan</wicri:regionArea><orgName type="university">Université d'Ibadan</orgName><placeName><settlement type="city">Ibadan</settlement><region type="region">État d'Oyo</region></placeName></affiliation></author><author><name sortKey="Ajayi, Funmilayo O" sort="Ajayi, Funmilayo O" uniqKey="Ajayi F" first="Funmilayo O." last="Ajayi">Funmilayo O. 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Concentrations of the chloroquine metabolites in the liver, heart, lungs, kidney and spleen were 34 to 250 times higher than their plasma concentrations 24 h after the drugs had been injected. Urinary excretion of the drugs was studied in rats after single intravenous administration of 2ṁ5, 5 or 10 mg kg−1 doses. The total estimated urinary excretion of desethylchloroquine and bisdesethylchloroquine was 25 and 64% respectively of the administered dose, with the maximum urinary excretion occurring on the first day. The results show that the desethylmetabolites of chloroquine are concentrated in the tissues in the same manner as the parent compound.</div></front></TEI><affiliations><list><country><li>Nigeria</li></country><region><li>État d'Oyo</li></region><settlement><li>Ibadan</li></settlement><orgName><li>Université d'Ibadan</li></orgName></list><tree><country name="Nigeria"><region name="État d'Oyo"><name sortKey="Salako, L A" sort="Salako, L A" uniqKey="Salako L" first="L. 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